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Cdr Dicom




Category:Schick Category:Digital imaging software Category:Screenshot softwareResponse of striatal dopamine D2 receptor binding and metabolism to haloperidol and sulpiride treatment. The effects of acute and chronic treatment of rats with haloperidol or sulpiride on the striatal levels of dopamine D2 receptors and their binding capacity were examined in parallel experiments. For this purpose, animals were treated with haloperidol (0.1-10 mg/kg) or sulpiride (100-300 mg/kg) for 1 or 21 days. The long-term antipsychotic treatment with haloperidol reduced the number of striatal D2 binding sites with a maximum effect at 3 mg/kg. In contrast, haloperidol produced a decrease in the binding capacity of striatal D2 sites only after 21 days of treatment with this antipsychotic drug. In addition, both the binding capacity and the number of striatal D2 sites were unaffected by the long-term treatment with sulpiride. These results suggest that the long-term treatment with haloperidol and its immediate withdrawal can produce profound effects on the number and binding capacity of striatal D2 receptors.-ever healthcare use. This study also demonstrated that the effect of the intervention on healthcare utilization was mainly due to the effect on high-risk patients. It should be noted that as this study has relied on self-reports of visits to the clinic in order to define healthcare utilization, it may be subject to recall bias. In addition, there is the possibility of residual confounding as there is the potential for people with a high risk of hospitalization to be more or less likely to visit a healthcare provider if they are aware of a screening programme. Although the effect of the intervention on mortality outcomes was not statistically significant in this study, the intervention was associated with a significant reduction in cardiovascular mortality in the intervention arm (HR 0.53; 95% CI 0.31 to 0.90, *p* = 0.019). This relationship was strongest for men, with a non-significant reduction in all-cause mortality. Strengths and limitations {#Sec18} ------------------------- This study has several strengths. First, this study was an RCT of a population-based, community-wide screening programme for high-risk patients conducted in the community setting. The findings of this study may therefore have relevance in other healthcare contexts where screening for high-




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